Research
Energy balance
A 5% weight loss in obese women significantly improves the HOMA index of insulin sensitivity, but this improvement occurs without a significant change in circulating RBP4 levels.
Losing just 5% of your body weight through a moderate calorie deficit (approx. 600 kcal/day) can significantly improve your insulin sensitivity. You do not need to achieve drastic changes in every single biomarker to see metabolic benefits.
GoodQualifiesHIGH confidence
A 5% weight reduction significantly improved the homeostasis model assessment (HOMA) index but only slightly decreased adipose RBP4 gene expression. RBP4 serum levels, however, were not influenced by this amount of weight loss.
Why this rating
Interventional study with clear pre/post measurements in a controlled cohort.
Source
Retinol-Binding Protein 4 in Human Obesity
Jürgen Janke et al. · Diabetes · 2006
DOI 10.2337/db06-0616
cross_sectional · n=74Cited 353×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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