Micronutrients & recovery
Excessive selenium intake (above nutritional levels) is associated with an increased risk of type 2 diabetes, insulin resistance, and dyslipidemia.
Do not exceed the tolerable upper intake level of 400 µg/day. If you are not deficient, high-dose selenium supplementation may increase your risk of type 2 diabetes and insulin resistance. Focus on food sources rather than supplements unless advised by a doctor.
On the other hand, Se concentrations slightly above its nutritional levels have been shown to have adverse effects on a broad spectrum of neurological functions and to increase the risk of type-2 diabetes. ... Recent studies indicate that high levels of Se are associated with insulin resistance and dyslipidemia. ... elevated serum Se levels were related to an increased risk of dyslipidemia [49]. ... Se levels were positively associated with insulin resistance and blood glucose...
Why this rating
Based on cross-sectional studies and animal models; the paper notes the relationship 'remains unclear' and 'research opinion... remains inconsistent'.
Source
Biological Activity of Selenium and Its Impact on Human Health
Giuseppe Genchi et al. · International Journal of Molecular Sciences · 2023
DOI 10.3390/ijms24032633
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- Selenium's biological activity is primarily mediated through its incorporation into selenoproteins (containing selenocysteine), which support antioxidant defense systems, thyroid hormone metabolism, and neuroprotection.Good
- Selenium deficiency impairs immune function, increases susceptibility to infections (including HIV and COVID-19), and is linked to cardiovascular diseases such as Keshan disease and myocardial infarction.Moderate
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