Research
Micronutrients & recovery
Activation of PPAR-α by fibrates (e.g., fenofibrate, gemfibrozil) lowers triglycerides and raises HDL cholesterol by increasing fatty acid oxidation and lipoprotein lipase activity.
Fibrate medications help your body burn fat for energy and clear 'bad' fats (triglycerides) from your blood while boosting 'good' cholesterol (HDL). This reduces the risk of heart disease and stroke, especially if you have high triglycerides or metabolic syndrome.
GoodSupportsHIGH confidence
PPAR-α agonists are used for the treatment of dyslipidemia, which is characterized by decreased triglycerides levels and increased HDL-c levels in plasma [117]. This state can be achieved by increasing the production of the major component of HDL-c, called Apolipoprotein A-I and A-II (APO A-I & APO A-II) [118, 119] ... Moreover, PPAR-α PPAR-activation further decreases TG levels by amplifying the expression of lipoprotein lipase (LPL) [120] and inhibiting APO C-III in the liver.
Why this rating
Supported by extensive clinical use and cited studies on lipid profiles.
Source
Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases
Francisco Monsalve et al. · Mediators of Inflammation · 2013
narrative_reviewCited 349×
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