Hormonal
Genetic variants of the FOXO3 gene (specifically SNPs like rs2802292) are consistently associated with increased human longevity and reduced age-related mortality across diverse populations.
Your genetics play a significant role in how long you live, but they are not your destiny. Specific variants of the FOXO3 gene are linked to longevity, and this gene's activity can be influenced by your environment. You can support healthy aging by adopting lifestyle factors that activate FOXO3, such as caloric restriction and consuming phytochemicals like resveratrol and curcumin, which help regulate cellular stress and metabolism.
FOXO3, encoding the transcription factor forkhead box O-3 (FoxO3), is one of only two for which genetic polymorphisms have exhibited consistent associations with longevity in diverse human populations.
Why this rating
Based on multiple meta-analyses and GWAS data from diverse populations, though the exact causal variant remains to be fully delineated.
Source
<b><i>FOXO3:</i></b> A Major Gene for Human Longevity - A Mini-Review
Brian J. Morris et al. · Gerontology · 2015
DOI 10.1159/000375235
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