Energy balance
Caloric restriction and certain phytochemicals (e.g., resveratrol, curcumin, EGCG) can upregulate FOXO3 activity, leading to improved stress resistance, autophagy, and potentially extended lifespan.
You can support your body's natural longevity genes (like FOXO3) by managing your energy intake and consuming specific plant compounds. Try incorporating moderate caloric restriction or eating foods rich in polyphenols, such as green tea (EGCG), turmeric (curcumin), and resveratrol. These natural compounds help activate cellular repair mechanisms, reduce inflammation, and may protect against age-related diseases.
Caloric restriction results in activation of sirtuins, leading to activation of FoxOs, improved autophagy, amino acid recycling via inhibition of mTOR activity, and other mechanisms leading to a healthy ageing phenotype.
Why this rating
Evidence comes from model organisms and some human observational/cellular studies, but direct human lifespan extension data is limited.
Source
<b><i>FOXO3:</i></b> A Major Gene for Human Longevity - A Mini-Review
Brian J. Morris et al. · Gerontology · 2015
DOI 10.1159/000375235
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