Research
Hormonal
Rapamycin inhibits cell cycle arrest markers (p16, p21) and activates autophagy through an Nrf2-dependent mechanism.
To benefit from rapamycin's ability to stop cells from stopping dividing (cell cycle arrest), your body's Nrf2 antioxidant pathway must be functional.
GoodSupportsHIGH confidence
These observations were further confirmed in vivo using Nrf2KO mice... however, p16 levels were not significantly decreased in fat tissue.
Why this rating
Consistent findings across multiple cell types and in vivo models.
Source
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism
Rong Wang et al. · Aging Cell · 2017
DOI 10.1111/acel.12587
mechanism_only · n=16Cited 348×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Rapamycin inhibits the senescence-associated secretory phenotype (SASP) and reduces SA-β-gal staining in senescent cells through a mechanism independent of the Nrf2 pathway, likely involving Stat3 inhibition.Good
- Rapamycin inhibits the Stat3 pathway, which may explain its ability to suppress SASP independently of Nrf2.Moderate
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