Research
Hormonal
Rapamycin inhibits the Stat3 pathway, which may explain its ability to suppress SASP independently of Nrf2.
Rapamycin may reduce inflammation in aging cells by turning off the Stat3 signal, even if the cell's main antioxidant system (Nrf2) is broken.
ModerateQualifiesMEDIUM confidence
Our data using lung tissue from Nrf2KO mice showed that tissue from Nrf2KO mice have increased basal levels of p-Stat3, and rapamycin treatment reduced these levels.
Why this rating
Correlational evidence in specific tissues; not all cell types showed Stat3 changes.
Source
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism
Rong Wang et al. · Aging Cell · 2017
DOI 10.1111/acel.12587
mechanism_only · n=16Cited 348×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Rapamycin inhibits the senescence-associated secretory phenotype (SASP) and reduces SA-β-gal staining in senescent cells through a mechanism independent of the Nrf2 pathway, likely involving Stat3 inhibition.Good
- Rapamycin inhibits cell cycle arrest markers (p16, p21) and activates autophagy through an Nrf2-dependent mechanism.Good
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