Mixed

Moderate-to-high intensity exercise (70% max workload) for 60 minutes causes splanchnic hypoperfusion, leading to quantifiable small intestinal epithelial damage and increased small intestinal permeability in healthy men.

If you engage in prolonged, high-intensity exercise (like 60 minutes of cycling at 70% max effort), expect your gut barrier to become more permeable and sustain minor cellular damage due to reduced blood flow. This is a normal physiological response in healthy people and typically resolves quickly (within 1-2 hours). However, frequent or prolonged episodes without adequate recovery could contribute to chronic gut issues. Ensure you are well-hydrated and consider post-exercise nutrition that supports gut repair.