Hormonal
The association between high protein intake and diabetes risk is significantly modified by adiposity, being stronger in lean individuals and attenuated or non-significant in obese individuals.
If you are lean, be particularly cautious with very high protein intake, as this study links it to a higher diabetes risk in your subgroup. In obese individuals, this specific link was not observed, possibly because other factors like adiposity dominate the risk profile.
In the relation between total protein and diabetes... we only found an association in lean individuals... whereas there was no relation in obese participants.
Why this rating
Interaction terms were borderline significant (P ~ 0.08), and the number of non-obese diabetic participants was relatively small.
Source
Dietary Intake of Total, Animal, and Vegetable Protein and Risk of Type 2 Diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL Study
Ivonne Sluijs et al. · Diabetes Care · 2009
DOI 10.2337/dc09-1321
More from this paper
- High intake of total and animal protein is associated with an increased risk of type 2 diabetes, whereas vegetable protein intake shows no such association.Good
- Substituting 5% of energy from carbohydrates or fat with protein increases the risk of type 2 diabetes by approximately 30%, regardless of whether the displaced macronutrient is fat or carbs.Good
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