Research
Adherence
Optogenetic inhibition of LHA-LHb glutamatergic fibers acutely increases the consumption of a palatable liquid caloric reward.
Inhibiting the neural pathway from the lateral hypothalamus to the lateral habenula increases the consumption of palatable, high-calorie liquids. This suggests that this specific brain circuit acts as a suppressor of reward-driven eating, and its dysfunction could contribute to overconsumption of palatable foods.
GoodSupportsHIGH confidence
Furthermore, optogenetic inhibition of LHA-LHb glutamatergic fibers acutely increased the consumption of a palatable liquid caloric reward.
Why this rating
High-quality optogenetic manipulation with clear behavioral outcomes.
Source
Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward
Alice M. Stamatakis et al. · Journal of Neuroscience · 2016
mechanism_onlyCited 344×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →