Adherence
Optogenetic inhibition of LHA-LHb glutamatergic fibers acutely increases the consumption of a palatable liquid caloric reward.
Inhibiting the neural pathway from the lateral hypothalamus to the lateral habenula increases the consumption of palatable, high-calorie liquids. This suggests that this specific brain circuit acts as a suppressor of reward-driven eating, and its dysfunction could contribute to overconsumption of palatable foods.
Furthermore, optogenetic inhibition of LHA-LHb glutamatergic fibers acutely increased the consumption of a palatable liquid caloric reward.
Why this rating
High-quality optogenetic manipulation with clear behavioral outcomes.
Source
Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward
Alice M. Stamatakis et al. · Journal of Neuroscience · 2016
DOI 10.1523/jneurosci.1202-15.2016
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- Genetic ablation of lateral hypothalamic area (LHA) glutamatergic neurons increases daily caloric intake and body weight gain in mice fed a high-fat diet without altering general locomotor activity.Good
- Optogenetic stimulation of LHA-LHb glutamatergic fibers produces an aversive behavioral phenotype, while inhibition produces a place preference.Good
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