Adherence
Optogenetic stimulation of LHA-LHb glutamatergic fibers produces an aversive behavioral phenotype, while inhibition produces a place preference.
Stimulating the neural pathway from the lateral hypothalamus to the lateral habenula is experienced as aversive by mice, while inhibiting it is experienced as rewarding. This suggests that this circuit normally suppresses the consumption of palatable foods, and its inhibition removes this suppression, leading to increased eating.
In vivo optogenetic inhibition of LHA-LHb glutamatergic fibers produced a real-time place preference, whereas optogenetic stimulation of LHA-LHb glutamatergic fibers had the opposite effect.
Why this rating
High-quality optogenetic manipulation with clear behavioral outcomes.
Source
Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward
Alice M. Stamatakis et al. · Journal of Neuroscience · 2016
DOI 10.1523/jneurosci.1202-15.2016
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- Genetic ablation of lateral hypothalamic area (LHA) glutamatergic neurons increases daily caloric intake and body weight gain in mice fed a high-fat diet without altering general locomotor activity.Good
- Optogenetic inhibition of LHA-LHb glutamatergic fibers acutely increases the consumption of a palatable liquid caloric reward.Good
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