Research
Mixed
Dual fortification of salt with both iron and iodine is more effective than iodine-only fortification in reducing goiter prevalence in iron-deficient, goitrous children.
For communities with goiter and anemia, dual-fortified salt (iodine + iron) is superior to iodized salt alone.
GoodSupportsHIGH confidence
In this study, addition of encapsulated Fe to iodized salt improved the efficacy of iodine in goitrous children with a high prevalence of anemia.
Why this rating
Randomized, double-blind trial with significant results.
Source
The Impact of Iron and Selenium Deficiencies on Iodine and Thyroid Metabolism: Biochemistry and Relevance to Public Health
Michael Zimmermann et al. · Thyroid · 2002
DOI 10.1089/105072502761016494
narrative_reviewCited 343×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Iron deficiency anemia blunts the efficacy of iodine supplementation in reducing goiter size, and concurrent iron supplementation restores this efficacy.Good
- Selenium deficiency impairs the thyroid's ability to handle high iodine loads, potentially causing damage, and selenium supplementation must follow iodine normalization to prevent hypothyroidism.Good
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