Mixed
Four weeks of oral supplementation with Lactobacillus acidophilus NCFM preserves insulin sensitivity in subjects with normal glucose tolerance, impaired glucose tolerance, or type 2 diabetes compared to placebo, without affecting systemic inflammatory markers.
Taking 1 gram of Lactobacillus acidophilus NCFM daily for four weeks may help maintain insulin sensitivity in individuals with normal glucose tolerance, impaired glucose tolerance, or type 2 diabetes. This benefit occurs independently of changes in systemic inflammation, suggesting the mechanism is specific to this strain and not a general anti-inflammatory effect of probiotics.
In conclusion, intake of L. acidophilus NCFM for 4 weeks preserved insulin sensitivity compared with placebo, but did not affect the systemic inflammatory response.
Why this rating
Double-blinded, randomized, placebo-controlled trial in humans with rigorous measurement (hyperinsulinemic-euglycaemic clamps), though the sample size is moderate (n=45) and the effect on inflammation was null.
Source
Effects of<i>Lactobacillus acidophilus</i>NCFM on insulin sensitivity and the systemic inflammatory response in human subjects
Anne Sofie Andreasen et al. · British Journal Of Nutrition · 2010
DOI 10.1017/s0007114510002874
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