Mixed
Consumption of wheat gliadin and plant lectins (found in grains, legumes, and some vegetables) increases intestinal permeability ('leaky gut'), leading to endotoxemia, chronic inflammation, and potentially autoimmune diseases and insulin resistance.
Be aware that wheat and legumes contain antinutrients like gliadin and lectins, which may increase gut permeability and inflammation in some individuals. If you experience digestive issues, autoimmune conditions, or insulin resistance, consider reducing or eliminating these foods and observe any changes in symptoms. Prioritize whole, unprocessed foods.
gliadin... increases gut permeability by means of zonulin production... leads to increased gut permeability... chronic consumption of wheat... may lead to low-grade chronic inflammation... lectins... disrupt intestinal barrier and immunological function... increasing gut permeability... contribute to endotoxemia... and hence low-grade inflammation through TLR4 activation by LPS.
Why this rating
Based on in vitro and animal studies, with some human observational data, but the paper notes human studies are 'poorly studied'.
Source
The western diet and lifestyle and diseases of civilization
Pedro Carrera‐Bastos et al. · Research Reports in Clinical Cardiology · 2011
DOI 10.2147/rrcc.s16919
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