Hormonal
The combination of GH and IGF-I attenuates the hypoglycemia caused by IGF-I alone while maintaining better glucose tolerance than GH alone.
When treating catabolism, using IGF-I alone can dangerously lower blood sugar, often requiring dose reductions. Adding Growth Hormone to the regimen stabilizes blood glucose levels, preventing these lows without causing the high blood sugar typically associated with GH alone. This balance makes the combination therapy metabolically safer and more sustainable than IGF-I monotherapy.
GH attenuated the hypoglycemia induced by IGF-I as indicated by fewer hypoglycemic episodes and higher capillary blood glucose concentrations on GH/IGF-I... compared to IGF-I alone
Why this rating
Same study as N1, robust statistical significance.
Source
Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously.
Stuart Kupfer et al. · Journal of Clinical Investigation · 1993
DOI 10.1172/jci116212
More from this paper
- Simultaneous administration of Growth Hormone (GH) and Insulin-like Growth Factor I (IGF-I) produces significantly greater nitrogen retention (anabolism) than either agent administered alone.Good
- The combination of GH and IGF-I increases serum IGF-I concentrations and stabilizes the IGF-I pool by inducing IGFBP-3 and Acid-Labile Subunit (ALS), leading to greater anabolic efficacy.Good
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