Research
Hormonal
The combination of GH and IGF-I increases serum IGF-I concentrations and stabilizes the IGF-I pool by inducing IGFBP-3 and Acid-Labile Subunit (ALS), leading to greater anabolic efficacy.
The combination therapy works partly by increasing the amount of stable IGF-I in the blood. GH stimulates the production of binding proteins (IGFBP-3 and ALS) that protect IGF-I from rapid breakdown, allowing it to work more effectively and for longer periods than IGF-I alone.
GoodSupportsHIGH confidence
GH/IGF-I produced higher serum IGF-I concentrations... This observation was associated with increased concentrations of IGF binding protein 3 and acid-labile subunit on GH/IGF-I treatment
Why this rating
Robust biochemical measurements in a controlled setting.
Source
Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously.
Stuart Kupfer et al. · Journal of Clinical Investigation · 1993
DOI 10.1172/jci116212
crossover · n=7Cited 338×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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