Hormonal
Obesity directly causes chronic kidney disease (CKD) and end-stage renal disease (ESRD) through compensatory hyperfiltration, glomerular hypertension, and adipose-derived inflammatory mediators, independent of diabetes and hypertension.
Maintaining a healthy body weight is critical for kidney health. Obesity increases pressure inside the kidney's filtering units (glomeruli) and releases hormones that cause inflammation and scarring, leading to chronic kidney disease. This risk exists even if you do not have diabetes or high blood pressure. Preventing obesity through lifestyle changes is the most effective way to protect your kidneys.
Obesity is a potent risk factor for the development of kidney disease... In individuals affected by obesity, a (likely) compensatory mechanism of hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidney structure and raise the risk of developing CKD in the long-term.
Why this rating
Based on numerous large population-based studies and meta-analyses cited, though exact mechanisms are described as 'unclear'.
Source
Obesity and kidney disease: Hidden consequences of the epidemic
Csaba P. Kövesdy et al. · Indian Journal of Nephrology · 2017
DOI 10.4103/ijn.ijn_61_17
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