Research
Mixed
Epigenetic age acceleration, measured by DNA methylation clocks, is associated with increased risk of Cardiovascular Disease (CVD) and mortality.
Maintain cardiovascular health through lifestyle choices (diet, exercise, no smoking) as these factors influence epigenetic aging. While you cannot change your chronological age, keeping your epigenetic age close to your chronological age is associated with lower CVD risk and longer life expectancy.
GoodSupportsHIGH confidence
The DNAm PhenoAge is a powerful biomarker for measuring health- and life- span that relies on measurements from 513 CpG sites... This clock could conclusively predict CVD incidence using whole blood DNA methylation values.
Why this rating
Supported by multiple large studies and specific clocks (PhenoAge, GrimAge).
Source
DNA Methylation Biomarkers in Aging and Age-Related Diseases
Yasmeen Salameh et al. · Frontiers in Genetics · 2020
DOI 10.3389/fgene.2020.00171
narrative_reviewCited 334×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- DNA methylation-based epigenetic clocks serve as accurate biomarkers for predicting biological age, disease risk, and mortality, often outperforming traditional chronological age metrics.Good
- Specific DNA methylation alterations in blood (e.g., ABCG1, TXNIP, SLC30A8) can predict the onset of Type 2 Diabetes (T2D) prior to clinical diagnosis, offering a window for early detection.Good
- DNA methylation biomarkers in blood (e.g., ANK1, DAPK1, BDNF) are associated with Alzheimer's Disease (AD) risk and neuropathology, potentially enabling earlier detection.Moderate
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