Hormonal
In healthy individuals, chronological age itself does not cause insulin resistance; observed declines in insulin sensitivity with age are fully explained by age-related increases in body mass index (BMI) and fat mass.
Do not accept insulin resistance as an inevitable part of aging. This study shows that in healthy people, the decline in insulin sensitivity is actually driven by gaining weight (specifically fat mass) and changes in body composition, not age itself. Focus on maintaining a healthy BMI and body composition rather than blaming your age for metabolic changes.
We conclude that in healthy Europeans, age per se is not a significant cause of insulin resistance of glucose metabolism or lipolysis.
Why this rating
Large-scale cross-sectional analysis (n=1,146) using the gold-standard euglycemic insulin clamp technique across 20 European centers.
Source
Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR)
Eleuterio Ferrannini et al. · Diabetes · 1996
DOI 10.2337/diab.45.7.947
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