Hormonal
In lean women, insulin action declines with age specifically due to impaired suppression of free fatty acids (FFAs), which leads to substrate competition where FFAs are oxidized instead of glucose.
If you are a lean woman, be aware that your insulin sensitivity may decline with age due to how your body handles fat acids, not just weight gain. This is a specific biological mechanism (substrate competition) rather than just 'getting old'. Monitoring body composition and metabolic health is important even if your BMI remains low.
In the subgroup of lean women in whom insulin action declined with age, adding FFA suppression to a multiple regression equation canceled the association between age and insulin action.
Why this rating
Large sample size (n=1,146) with a specific subset (n=92 lean women with FFA data) allowing for multivariate regression analysis.
Source
Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR)
Eleuterio Ferrannini et al. · Diabetes · 1996
DOI 10.2337/diab.45.7.947
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →