Mixed
In critically ill ICU patients without acute kidney injury, a higher Sarcopenia Index (serum creatinine divided by serum cystatin C multiplied by 100) is independently associated with lower hospital and 90-day mortality and shorter duration of mechanical ventilation.
For ICU patients without kidney failure, calculating the ratio of serum creatinine to cystatin C (multiplied by 100) provides a better estimate of muscle mass and predicts survival better than using creatinine alone or standard nutritional scores. This index can help identify high-risk patients for early intervention.
After adjustment for Acute Physiology and Chronic Health Evaluation III, body surface area, and age, sarcopenia index was independently predictive of both hospital (p = 0.001) and 90-day mortality (p < 0.0001). Among the 131 patients on mechanical ventilator, the duration of mechanical ventilation was significantly lower on those with higher sarcopenia index (–1 d for each 10 unit of sarcopenia index [95% CI, –1.4 to –0.2; p = 0.006]).
Why this rating
Retrospective cohort study with a relatively small sample size (n=226) and moderate correlation with gold standard (r=0.62).
Source
Evaluating Muscle Mass by Using Markers of Kidney Function: Development of the Sarcopenia Index
Kianoush Kashani et al. · Critical Care Medicine · 2016
DOI 10.1097/ccm.0000000000002013
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