Mixed
Mediterranean Diet (MD) is the recommended first-choice diet for NAFL/NASH patients, improving hepatic steatosis and visceral fat, though its efficacy in advanced NASH requires further investigation.
Adopt a Mediterranean Diet rich in whole grains and healthy fats (MUFAs). This is the recommended first-line dietary approach to reduce liver fat and visceral fat. While it helps with insulin resistance and may reduce cardiovascular risk, its ability to reverse advanced NASH is not yet fully proven.
the Mediterranean diet (MD) pattern... recommended that the Mediterranean diet (MD) pattern... as the first-choice diet for patients with NAFL/NASH.
Why this rating
Supported by guidelines and studies showing improvement in steatosis and IR.
Source
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
Xiaohan Xu et al. · Signal Transduction and Targeted Therapy · 2022
DOI 10.1038/s41392-022-01119-3
More from this paper
- Weight loss of 10% or more through lifestyle interventions (hypocaloric diet and exercise) is necessary to achieve regression of liver fibrosis in patients with NAFL/NASH.Good
- Targeting de novo lipogenesis (DNL) via ACC inhibitors (e.g., GS-0976, MK-4074) significantly reduces hepatic steatosis and DNL in patients with NASH.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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