Research
Hormonal
Semaglutide 2.4mg weekly induces significantly greater weight loss (mean 14.9%) compared to lifestyle interventions alone (mean 2.4%) in adults without diabetes.
Semaglutide 2.4mg taken once weekly, combined with a modest caloric deficit, can lead to an average 15% body weight loss in people without diabetes. This is significantly more effective than lifestyle changes alone and helps counteract the biological drive to regain weight.
StrongSupportsHIGH confidence
In clinical trials, 56 weeks of semaglutide 2.4mg in combination with a 500 kcal/day deficit diet resulted in 14.9% WL vs 2.4% with placebo in people without diabetes.
Why this rating
Based on large, multi-center clinical trials (STEP 1) cited in the review.
Source
New therapies for obesity
Dimitris Papamargaritis et al. · Cardiovascular Research · 2022
DOI 10.1093/cvr/cvac176
narrative_reviewCited 69×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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Related findings · Hormonal
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