Research
Hormonal
Bariatric surgery (specifically Roux-en-Y gastric bypass and sleeve gastrectomy) consistently achieves sustained weight loss of 25-30% and improves cardiovascular outcomes, serving as the current gold standard for efficacy.
Bariatric surgery (like RYGB or SG) is the most effective current treatment for obesity, achieving 25-30% sustained weight loss and reducing cardiovascular risk. It works by altering gut hormones to reduce appetite, not just by restricting stomach size.
StrongSupportsHIGH confidence
RYGB results in 30% WL over the first postoperative year and a sustained 25-27% WL long-term. SG leads to 25% WL at the first postoperative years and around 20% WL long-term.
Why this rating
Supported by the large Swedish Obese Subjects (SOS) study and other observational cohorts.
Source
New therapies for obesity
Dimitris Papamargaritis et al. · Cardiovascular Research · 2022
DOI 10.1093/cvr/cvac176
narrative_reviewCited 69×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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