Mixed

Combining SGLT-2 inhibitors with appetite-suppressing agents (like GLP-1 receptor agonists or phentermine) overcomes the counter-regulatory increase in food intake, resulting in significantly greater weight loss (3–7.3 kg) than either drug alone.

If SGLT-2 inhibitors alone aren't moving the needle enough, combining them with an appetite suppressant (like a GLP-1 agonist or phentermine) is a proven strategy. This combo tackles weight loss from two angles: peeing out calories and feeling less hungry. Clinical trials show this can lead to 3–7 kg of weight loss, significantly more than either drug used by itself.