Research
Hormonal
Phlebotomy in humans with high-normal ferritin and impaired glucose tolerance increases adiponectin and improves glucose tolerance.
For individuals with pre-diabetes and high-normal ferritin, therapeutic phlebotomy can be an effective non-pharmacological intervention to improve insulin sensitivity and glucose control.
GoodSupportsHIGH confidence
Phlebotomy of humans with impaired glucose tolerance and ferritin values in the highest quartile of normal increased adiponectin and improved glucose tolerance.
Why this rating
Human clinical trial data showing causal improvement in glucose tolerance and adiponectin.
Source
Adipocyte iron regulates adiponectin and insulin sensitivity
J. Scott Gabrielsen et al. · Journal of Clinical Investigation · 2012
DOI 10.1172/jci44421
mechanism_only · n=110Cited 328×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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