Research
Hormonal
Hereditary hemochromatosis (HH) is associated with increased insulin sensitivity and higher adiponectin levels due to low adipocyte iron, despite systemic iron overload.
HH patients often have better insulin sensitivity than expected due to low adipocyte iron, but this does not negate the risk of organ damage from systemic iron overload.
GoodQualifiesHIGH confidence
Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity.
Why this rating
Supported by both mouse models (Hfe-/-) and human HH patient data.
Source
Adipocyte iron regulates adiponectin and insulin sensitivity
J. Scott Gabrielsen et al. · Journal of Clinical Investigation · 2012
DOI 10.1172/jci44421
mechanism_only · n=110Cited 328×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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