Energy balance
High-intensity or chronic exercise induces nuclear translocation of Transcription Factor EB (TFEB) in skeletal muscle, which independently regulates glucose homeostasis, mitochondrial biogenesis, and metabolic flexibility without requiring PGC1α.
To maximize metabolic flexibility and mitochondrial health, your exercise routine must be intense enough or chronic enough to trigger specific cellular signals. Mild activity may not be sufficient to activate TFEB, a key regulator of glucose and fat metabolism. Focus on progressive, high-intensity training to ensure your muscles adapt efficiently.
Here we show that the calcineurin-TFEB axis plays a major role in the metabolic adaptations that occur during physical exercise. By using gain- and loss-of-function approaches, we show that TFEB regulates mitochondrial biogenesis and glucose uptake independently of PGC1a.
Why this rating
High-quality mechanistic evidence using multiple mouse models (KO, overexpression, conditional) and human-relevant pathways, though translated from murine models.
Source
Transcription Factor EB Controls Metabolic Flexibility during Exercise
Gelsomina Mansueto et al. · Cell Metabolism · 2016
DOI 10.1016/j.cmet.2016.11.003
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →