Hormonal
Low levels of adiponectin, common in obesity, are associated with increased risk and progression of various cancers due to the loss of its anti-proliferative and pro-apoptotic effects.
Obesity often leads to low levels of adiponectin, a hormone that normally helps prevent cancer by stopping abnormal cell growth and promoting cell death. Maintaining a healthy weight can help keep adiponectin levels high, potentially reducing the risk of several cancers, including breast, colon, and endometrial cancer.
Taken together, high adiponectin levels have attenuating effects on cancer expression and progression. Its inverse relationship with fat mass supports adiponectin’s role in cancer as it relates to obesity and weight status.
Why this rating
Supported by multiple studies showing inverse correlation between adiponectin levels and cancer risk.
Source
Adipose tissue, obesity and adipokines: role in cancer promotion
Andrea Booth et al. · Hormone Molecular Biology and Clinical Investigation · 2015
DOI 10.1515/hmbci-2014-0037
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