Mixed
Modern diets with an Omega-6 to Omega-3 ratio of 20-50:1, compared to the evolutionary ideal of 1-2:1, drive chronic inflammation and chronic disease by shifting lipid mediator production toward pro-inflammatory pathways.
Reduce your intake of seed and vegetable oils (corn, soybean, sunflower, safflower) which are high in Omega-6. Increase intake of Omega-3 sources like fatty fish, algae, or flax/chia seeds. Aim for a dietary ratio closer to 4-5:1 rather than the typical 20:1 found in modern diets to lower systemic inflammation.
Overconsumption of n-6 PUFAs with low intake of n-3 PUFAs is highly associated with the pathogenesis of many modern diet-related chronic diseases... Due to higher ratios of n-6/n-3 in modern diets, larger quantities of LA- and AA-derived lipid mediators are produced, becoming the main causes of the formation of thrombus and atheroma, the allergic and inflammatory disorders, and the proliferation of cells...
Why this rating
This is a review article synthesizing observational and mechanistic data, not a primary clinical trial.
Source
Overconsumption of Omega-6 Polyunsaturated Fatty Acids (PUFAs) versus Deficiency of Omega-3 PUFAs in Modern-Day Diets: The Disturbing Factor for Their “Balanced Antagonistic Metabolic Functions” in the Human Body
Abeba Haile Mariamenatu et al. · Journal of Lipids · 2021
DOI 10.1155/2021/8848161
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