Hormonal
Metformin administration (850-1700 mg) reduces caloric intake and hunger ratings in a dose-dependent manner in obese women with type II non-insulin-dependent diabetes.
If you have type 2 diabetes and obesity, metformin can help you lose weight by reducing your appetite and calorie intake, especially if you have struggled to lose weight with diet alone. The study used doses of 850-1700 mg daily, combined with a modest caloric restriction (1200 kcal/day).
The prior administration of metformin produced a reduction in calorie intake after each of the two doses of metformin treatment. The 1700-mg metformin dose had the most marked appetite suppressant action. Similarly, hunger ratings were significantly lowered after metformin, and the effect was most pronounced after the administration of 1700 mg of metformin.
Why this rating
Randomized, double-blind, placebo-controlled design with a Latin square design for the acute phase and a 24-week trial for weight loss.
Source
Metformin Decreases Food Consumption and Induces Weight Loss in Subjects with Obesity with Type II Non‐Insulin‐Dependent Diabetes
Amy S. Lee et al. · Obesity Research · 1998
DOI 10.1002/j.1550-8528.1998.tb00314.x
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