Research
Mixed
Synbiotic supplementation (Lactobacillus/Bifidobacterium + GOS) during a low-carbohydrate high-protein weight loss program does not significantly improve body composition or weight loss outcomes compared to placebo.
If you are following a low-carb, high-protein weight loss diet, adding this specific synbiotic supplement (Lactobacillus/Bifidobacterium + GOS) for 3 months will not help you lose more weight or body fat than the diet alone. The diet works; the supplement did not add to it in this study.
ModerateRefutesMEDIUM confidence
The results obtained indicate that there were no statistically significant differences in the body composition parameters (body mass, waist circumstance, BMI, body fat mass, body fat percentage, body lean mass, bone mineral content (as measured by DXA) and obesity-related biomarkers (blood glucose, as measured by HbA1C levels)) between the placebo and synbiotic groups at the end of the clinical trial (three-month synbiotic intervention)
Why this rating
Randomized placebo-controlled trial, but small sample size (n=20) and short duration (3 months).
Source
Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity
И. Н. Сергеев et al. · Nutrients · 2020
DOI 10.3390/nu12010222
rct · n=20Cited 317×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Mixed
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