Research
Hormonal
Advanced paternal age is associated with decreased sperm parameters (except concentration), increased DNA fragmentation, and higher risk of genetic disorders in offspring.
As men age, sperm quality declines, DNA fragmentation increases, and the risk of genetic disorders in children rises. Couples with advanced paternal age should be counseled cautiously regarding ART success rates and potential genetic risks.
GoodRefutesHIGH confidence
A negative association between increasing paternal age and testicular volume was noted by several studies... In a study it was found that compared to the age group 18–40 years, men aged > 75 years had 31% smaller mean testicular volume
Why this rating
The paper cites multiple studies and a meta-analysis confirming the trend, though it notes guidelines do not yet support routine DNA integrity assessment.
Source
Lifestyle and fertility: the influence of stress and quality of life on male fertility
Alessandro Ilacqua et al. · Reproductive Biology and Endocrinology · 2018
DOI 10.1186/s12958-018-0436-9
narrative_reviewCited 308×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Psychological stress negatively impacts male fertility by reducing luteinizing hormone and testosterone pulsing, which in turn impairs spermatogenesis and sperm quality.Moderate
- Obesity and high-fat diets impair male fertility by increasing oxidative stress, reducing sperm concentration, motility, and DNA integrity, while moderate exercise and healthy diets (e.g., Mediterranean) can improve these parameters.Moderate
- Increased scrotal temperature from tight clothing, hot baths, or laptop use impairs fertility by increasing ROS generation, DNA fragmentation, and apoptosis.Moderate
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