Research
Mixed
Bariatric surgery is NOT associated with a significantly lower risk of incident cerebrovascular disease (stroke) compared to usual medical care in patients with type 2 diabetes and severe obesity at 5 years.
For patients with severe obesity and type 2 diabetes, bariatric surgery is associated with a significantly lower risk of coronary artery disease, but the reduction in stroke risk was not statistically significant at 5 years.
ModerateRefutesMEDIUM confidence
The incidence of cerebrovascular disease was not significantly different between groups at 5 years (0.7% in the surgical group vs 1.7% in the nonsurgical group; hazard ratio, 0.69 [95% CI, 0.38-1.25]).
Why this rating
Retrospective matched cohort study.
Source
Association Between Bariatric Surgery and Macrovascular Disease Outcomes in Patients With Type 2 Diabetes and Severe Obesity
David Fisher et al. · JAMA · 2018
DOI 10.1001/jama.2018.14619
cohort · n=20235Cited 304×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Bariatric surgery is associated with a significantly lower risk of incident macrovascular disease (composite of coronary and cerebrovascular events) compared to usual medical care in patients with type 2 diabetes and severe obesity.Moderate
- Bariatric surgery is associated with a significantly lower risk of incident coronary artery disease (CAD) compared to usual medical care in patients with type 2 diabetes and severe obesity.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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