Mixed
Metabolic dysfunction (Metabolic Syndrome) significantly increases CHD risk regardless of body weight, with metabolically unhealthy normal weight individuals having more than double the risk of metabolically healthy normal weight individuals.
If you are normal weight, you are not immune to heart disease. If you have high blood pressure, high triglycerides, low HDL, high blood sugar, or a large waist, your risk is more than double that of a normal weight person with healthy metabolic markers. Address these metabolic issues through lifestyle changes or medication.
MetS was strongly positively associated with CHD risk, regardless of adiposity, with a HR of 2.15 (95% CI 1.79, 2.57: p<0.0001) for metabolically unhealthy normal weight participants with MetS
Why this rating
Large sample size, robust statistical adjustment, consistent results across sensitivity analyses.
Source
Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis
Camille Lassale et al. · European Heart Journal · 2017
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