Mixed
Dietary habits are the dominant factor explaining inter-individual variation in the plasma metabolome, accounting for more variance than genetics or the gut microbiome for the majority of metabolites.
Your diet has a significantly larger impact on your blood metabolite levels than your genetics or gut bacteria do for most metabolic markers. Focusing on food quality and specific food items (like coffee or fish) can directly alter your metabolic profile more effectively than trying to change your genetic makeup.
Inter-individual variations in 610 metabolites were mostly explained by diet, 85 were explained by the gut microbiome and 38 were explained by genetics... diet or the microbiome being particularly dominant.
Why this rating
Large cohort (n=1,368), extensive phenotyping, replication cohorts, and robust statistical methods (LASSO, MR).
Source
Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome
Lianmin Chen et al. · Nature Medicine · 2022
DOI 10.1038/s41591-022-02014-8
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