Mixed
Higher epigenetic age (Hannum age) is independently associated with increased all-cause mortality risk in older adults, whereas longer telomere length is associated with decreased mortality risk.
For older adults, biological age (measured by DNA methylation) and telomere length are independent predictors of mortality. While you cannot directly 'dose' these markers, maintaining health through lifestyle factors may influence these biological processes. Regular health check-ups are crucial, as these biomarkers offer a more nuanced view of aging risk than chronological age alone.
a one standard deviation increase in baseline epigenetic age was linked to a 25% increased mortality risk (P = 1.4 (cid:2) 10(cid:3)4) whereas... a one standard deviation increase in baseline telomere length was independently linked to an 11% decreased mortality risk (P = 0.047).
Why this rating
Longitudinal data from two large birth cohorts (LBC1921 and LBC1936) with rigorous statistical modeling (Cox proportional hazards), though limited by sample size in the older cohort.
Source
The epigenetic clock and telomere length are independently associated with chronological age and mortality
Riccardo E. Marioni et al. · International Journal of Epidemiology · 2016
DOI 10.1093/ije/dyw041
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