Mixed
The PER3 VNTR polymorphism in humans affects sleep homeostasis, specifically accelerating the buildup of sleep pressure and altering slow-wave sleep, independent of circadian phase shifts.
If you have the PER3 long variant (often associated with morningness), your brain builds sleep pressure faster. This means you may feel sleepier earlier in the day and have more slow-wave sleep. Align your schedule with this faster buildup to avoid excessive sleepiness during the day or difficulty staying awake.
These data imply that the PER3 VNTR polymorphism affects the homeostatic aspect of sleep regulation.
Why this rating
Based on association studies in humans (Viola et al., 2007) and transgenic models; causal mechanisms in humans are inferred from mouse data and genetic association.
Source
Circadian clock genes and sleep homeostasis
Paul Franken et al. · European Journal of Neuroscience · 2009
DOI 10.1111/j.1460-9568.2009.06723.x
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