Research
Mixed
Genetic variants associated with Intrinsic Epigenetic Age Acceleration (IEAA) are enriched in pathways related to lipid metabolism, immune function, and hematopoietic stem cell properties, independent of DNA methylation levels at the clock's constituent CpG sites.
Research shows that your genetic makeup influences how your body ages through immune and lipid pathways. While you cannot change your genes, understanding these links highlights the importance of managing inflammation and lipid levels for healthy aging.
GoodSupportsHIGH confidence
We find evidence for shared genetic loci associated with the Horvath clock and expression of transcripts encoding genes linked to lipid metabolism and immune function. Notably, these loci are independent of those reported to regulate DNA methylation levels at constituent clock CpGs.
Why this rating
Large-scale GWAS with rigorous colocalization analysis confirming independent genetic effects.
Source
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
Daniel L. McCartney et al. · Genome biology · 2021
DOI 10.1186/s13059-021-02398-9
Meta-analysis · 37 studiesCited 300×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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