Hormonal
Quercetin supplementation reduces systemic inflammation (specifically TNF-α, IL-6, and CRP) in humans, which may mitigate risks associated with obesity and type 2 diabetes.
If you are looking to reduce inflammation associated with obesity or metabolic risk, quercetin supplementation (150mg daily for 6 weeks) has been shown in human studies to lower TNF-α levels. This is distinct from dietary intake, which is often much lower. Consult a doctor before starting, especially if you have existing health conditions.
A six-week regiment of 150 milligrams of quercetin taken daily by human subjects significantly lowered cytokine TNF-α serum concentrations [30].
Why this rating
The paper cites one human study (Ref 30) but relies heavily on in vitro and animal models for mechanistic details, limiting the strength of human-specific claims.
Source
Therapeutic Effects of Quercetin on Inflammation, Obesity, and Type 2 Diabetes
Shuang Chen et al. · Mediators of Inflammation · 2016
DOI 10.1155/2016/9340637
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