Hormonal
Quercetin improves glucose metabolism and reduces obesity markers in animal models of type 2 diabetes and high-fat diet-induced obesity through MAPK and AMPK signaling pathways.
Animal studies show quercetin can reduce fat mass and improve glucose metabolism by activating specific cellular pathways (MAPK/AMPK). However, these results have not been consistently replicated in human clinical trials, so it should not be relied upon as a primary weight loss or diabetes treatment.
Studies showed that quercetin prevents high-fat diet (HFD) induced obesity in C57B1/6 mice... Specifically, the supplement-fed mice experienced a reduction in body weight, liver weight, and amount of total white adipose tissue.
Why this rating
The evidence is derived entirely from animal models (mice, rats) and in vitro studies, with no direct human clinical trial data for obesity/glucose metrics provided in this review.
Source
Therapeutic Effects of Quercetin on Inflammation, Obesity, and Type 2 Diabetes
Shuang Chen et al. · Mediators of Inflammation · 2016
DOI 10.1155/2016/9340637
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