Research
Adherence
Sedentary lifestyle is a significant inducer of insulin resistance, and increasing physical activity reduces the risk of Type 2 Diabetes.
Aim to burn an extra 500 calories per week through physical activity. This could be 100 minutes of moderate walking or 50 minutes of vigorous exercise. This simple increase lowers your lifetime risk of Type 2 Diabetes by 6%.
GoodSupportsHIGH confidence
A sedentary lifestyle increases the likelihood of developing IR... For each 500 kcal/week increment in energy expenditure as a result of physical activity, the lifetime risk of T2DM decreases by 6%.
Why this rating
Supported by multiple cited studies (26, 27, 28).
Source
Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and pre-diabetes screening: Developments in research and prospects for the future
Qi Tang et al. · Drug Discoveries & Therapeutics · 2015
DOI 10.5582/ddt.2015.01207
narrative_reviewCited 298×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Insulin resistance (IR) is a primary pathophysiological driver of Type 2 Diabetes Mellitus (T2DM) and metabolic syndrome, and can be effectively screened using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR).Good
- Dietary factors, specifically simple sugars (fructose) and dietary fat, contribute to the development of insulin resistance and obesity.Good
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →