Research
Micronutrients & recovery
Inhibition of ceramide biosynthesis improves hepatic steatosis (fatty liver) in obese mice, associated with reduced hepatic SOCS-3 expression.
Blocking ceramide production reduces fatty liver in obese mice, likely by lowering SOCS-3 levels.
GoodSupportsHIGH confidence
Hematoxylin and eosin staining showed pronounced steatosis with macrovesicular fat accumulation in obese mice... which was significantly reduced after myriocin treatment... hepatic triglycerides... were also reduced in myriocin-treated obese mice... myriocin treatment resulted in significant reductions in hepatic SOCS-3 expression in the DIO models.
Why this rating
Consistent findings across obese mouse models.
Source
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome
Guang Yang et al. · American Journal of Physiology-Endocrinology and Metabolism · 2009
DOI 10.1152/ajpendo.91014.2008
mechanism_onlyCited 294×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Inhibition of de novo ceramide biosynthesis using myriocin reduces body weight and fat mass in obese mice by increasing energy expenditure and metabolic rate, independent of food intake.Good
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