Research
Mixed
Disruption of circadian rhythms and sleep loss alters gut microbiota composition (dysbiosis), leading to increased intestinal permeability and systemic low-grade inflammation, which contributes to metabolic dysfunction and mood disorders.
Prioritize consistent sleep schedules and duration. If you are a shift worker or experience jet lag, be aware that your gut health and metabolic risk are compromised. Restoring circadian alignment is a prerequisite for optimal gut barrier function and metabolic health.
ModerateSupportsMEDIUM confidence
Circadian rhythm disorders appear to damage the gut-microbiota equilibrium, and this type of damage is associated with the occurrence of metabolic syndrome... Increase in permeability of the epithelial barrier (primarily caused by an increase in lipopolysaccharide (LPS) in the body and subsequent bacterial translocation) is an important cause of the characteristic feature of metabolic dysfunction—chronic low-level inflammation in vivo.
Why this rating
Based on animal models and observational human studies; the paper notes human RCTs are rare and sample sizes are small.
Source
The Role of Microbiome in Insomnia, Circadian Disturbance and Depression
Yuanyuan Li et al. · Frontiers in Psychiatry · 2018
DOI 10.3389/fpsyt.2018.00669
narrative_reviewCited 294×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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