Research
Energy balance
Obesity results from a complex interaction between environmental factors (e.g., ultra-processed foods, reduced physical activity) and genetic susceptibility, rather than environmental factors alone.
Recognize that your genetics may predispose you to weight gain, but this does not mean you are powerless. Understanding this interaction can help you adopt more effective, personalized strategies for managing your weight, such as working with healthcare providers on targeted interventions.
StrongQualifiesVERY_HIGH confidence
While recent environmental changes are undoubtedly responsible for the global rise in obesity, inherited differences between people can largely explain why many are prone to becoming overweight, while others are protected from excessive weight gain. In other words, obesity results from an interaction between environmental and (epi)genetic factors.
Why this rating
Supported by twin studies, family studies, and genetic loci identification.
Source
Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy
Valdemar Brimnes Ingemann Johansen et al. · Cell · 2025
narrative_reviewCited 34×
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