Research
Hormonal
NCL-1 (TRIM2/Brat) mediates lifespan extension in major longevity pathways by limiting nucleolar size and reducing fibrillarin expression.
In C. elegans, the protein NCL-1 is essential for the lifespan benefits of various longevity pathways. It works by reducing the size of the nucleolus and lowering fibrillarin levels. This suggests that regulating nucleolar function is a critical step in extending life in these genetic models.
StrongSupportsVERY_HIGH confidence
Here we show that NCL-1/TRIM2/Brat tumour suppressor extends lifespan and limits nucleolar size in the major C. elegans longevity pathways, as part of a convergent mechanism focused on the nucleolus.
Why this rating
Genetic evidence in C. elegans is robust, showing NCL-1 is required for lifespan extension in multiple mutants.
Source
Small nucleoli are a cellular hallmark of longevity
Varnesh Tiku et al. · Nature Communications · 2017
DOI 10.1038/ncomms16083
mechanism_only · n=10Cited 294×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Small nucleolar size is a conserved cellular hallmark of longevity and metabolic health across multiple species, including C. elegans, Drosophila, mice, and humans.Good
- Knockdown of fibrillarin reduces nucleolar size and extends lifespan in wild-type C. elegans.Good
- In humans, modest dietary restriction combined with exercise is associated with smaller nucleoli in muscle biopsies.Moderate
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