Research
Mixed
Knockdown of fibrillarin reduces nucleolar size and extends lifespan in wild-type C. elegans.
Reducing the expression of the nucleolar protein fibrillarin extends lifespan in C. elegans. This suggests that inhibiting specific aspects of ribosome production can promote longevity.
GoodSupportsHIGH confidence
Knockdown of fibrillarin also reduces nucleolar size and extends lifespan.
Why this rating
Genetic evidence in C. elegans is strong.
Source
Small nucleoli are a cellular hallmark of longevity
Varnesh Tiku et al. · Nature Communications · 2017
DOI 10.1038/ncomms16083
mechanism_only · n=10Cited 294×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- NCL-1 (TRIM2/Brat) mediates lifespan extension in major longevity pathways by limiting nucleolar size and reducing fibrillarin expression.Strong
- Small nucleolar size is a conserved cellular hallmark of longevity and metabolic health across multiple species, including C. elegans, Drosophila, mice, and humans.Good
- In humans, modest dietary restriction combined with exercise is associated with smaller nucleoli in muscle biopsies.Moderate
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