Research
Mixed
Sibutramine and Orlistat are effective pharmacological interventions for weight loss, achieving approximately 5% to 10% weight reduction maintained for up to 2 years.
Sibutramine and Orlistat are FDA-approved medications for long-term weight loss. They typically help patients lose 5-10% of their body weight, which is maintained for up to 2 years. Sibutramine works by increasing satiety, while Orlistat blocks fat absorption. They are indicated for those with a BMI over 30, or over 27 with health complications.
GoodSupportsHIGH confidence
Both orlistat and sibutramine induce 5% to 10% weight reduction, with maintenance for up to 2 yr (40).
Why this rating
Cites randomized controlled trials and meta-analyses.
Source
Anesthetic Considerations for Bariatric Surgery
Babatunde Ogunnaike et al. · Anesthesia & Analgesia · 2002
DOI 10.1097/00000539-200212000-00061
narrative_reviewCited 293×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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