Research
Energy balance
The UCP3 C→T silent polymorphism in exon 3 is not significantly associated with metabolic rate or obesity in Pima Indians.
Testing for the UCP3 C→T polymorphism is unlikely to provide useful information for managing weight or metabolic rate in Pima Indians, as this specific variant shows no significant association with these outcomes.
ModerateRefutesMEDIUM confidence
No significant association was found for the C→T silent polymorphism in exon 3 of UCP3 with metabolic rate.
Why this rating
Statistically non-significant result in a specific population; useful for ruling out UCP3's role in this context.
Source
Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians
Ken Walder · Human Molecular Genetics · 1998
DOI 10.1093/hmg/7.9.1431
cross_sectional · n=872Cited 293×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Heterozygosity for UCP2 exon 4 (Ala/Val) and exon 8 (ins/del) polymorphisms is associated with significantly higher sleeping metabolic rate and 24-hour energy expenditure in young Pima Indians.Moderate
- The UCP2 exon 8 insertion/deletion polymorphism is associated with lower Body Mass Index (BMI) in Pima Indians over the age of 45, specifically in heterozygotes.Moderate
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