Research
Mixed
Higher consumption of an unhealthy 'Western' dietary pattern is independently associated with smaller left hippocampal volume in older adults, while higher consumption of a healthy 'prudent' dietary pattern is associated with larger left hippocampal volume.
Focus on eating a 'prudent' diet rich in vegetables, fruit, whole grains, and fish, while minimizing 'Western' foods like processed meats, fried foods, and sugary drinks. This dietary pattern is associated with larger hippocampal volume, a brain region critical for memory and mood, in older adults.
GoodSupportsHIGH confidence
Every one standard deviation increase in healthy 'prudent' dietary pattern was associated with a 45.7 mm3 (standard error 22.9 mm3) larger left hippocampal volume, while higher consumption of an unhealthy 'Western' dietary pattern was (independently) associated with a 52.6 mm3 (SE 26.6 mm3) smaller left hippocampal volume.
Why this rating
Longitudinal human study with MRI data, controlling for multiple covariates, though observational in nature.
Source
Western diet is associated with a smaller hippocampus: a longitudinal investigation
Felice N. Jacka et al. · BMC Medicine · 2015
DOI 10.1186/s12916-015-0461-x
cohort · n=255Cited 292×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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