Research

Mixed

Higher consumption of an unhealthy 'Western' dietary pattern is independently associated with smaller left hippocampal volume in older adults, while higher consumption of a healthy 'prudent' dietary pattern is associated with larger left hippocampal volume.

Focus on eating a 'prudent' diet rich in vegetables, fruit, whole grains, and fish, while minimizing 'Western' foods like processed meats, fried foods, and sugary drinks. This dietary pattern is associated with larger hippocampal volume, a brain region critical for memory and mood, in older adults.

GoodSupportsHIGH confidence
Every one standard deviation increase in healthy 'prudent' dietary pattern was associated with a 45.7 mm3 (standard error 22.9 mm3) larger left hippocampal volume, while higher consumption of an unhealthy 'Western' dietary pattern was (independently) associated with a 52.6 mm3 (SE 26.6 mm3) smaller left hippocampal volume.
Felice N. Jacka et al. · BMC Medicine · 2015

Why this rating

Longitudinal human study with MRI data, controlling for multiple covariates, though observational in nature.

Source

Western diet is associated with a smaller hippocampus: a longitudinal investigation

Felice N. Jacka et al. · BMC Medicine · 2015

DOI 10.1186/s12916-015-0461-x

cohort · n=255Cited 292×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →